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Symptoms: Symptoms following overdosage with acetylcysteine have been similar to those of anaphylactoid reactions noted under "Adverse Reactions", but they may be more severe. Hypotension appears to be especially prominent. There is also a theoretical risk of hepatic encephalopathy.
Treatment: It has been suggested that generalised reactions to acetylcysteine can be treated with intravenous injection of an antihistamine, and infusion of acetylcysteine should be temporarily stopped but can be restarted at a slower rate without further reaction.
